CD44 plays a key role in melanoma cell proliferation, which is induced by hyaluronic acid through the activation of mitogen-activated protein kinase (MAPK), Rac (a member of the Rho family of small GTPases), and phosphoinositol-3 kinase (PI3K) signaling pathways, which are essential for cancer cell survival [61]. Here, AKT1 is linked to cancer.