ADAM17 and Sepsis: Furthermore, MMP-9 knock-out mice are better protected against endotoxin shock than wild-type animals and mice treated with MMP-inhibitors (broad spectrum or combined against MMP-8, MMP-9 and a disintegrin and metalloproteinase17 (ADAM17)/tumor necrosis factor-α-converting enzyme (TACE)) are more likely to survive an endotoxin challenge or caecal ligation and puncture-induced sepsis [17,18,19].