CD8A and neoplasm: DOTAP/oncoprotein E7 of papillomavirus was evaluated for its anti-cancer activity; E7 peptide formulated with DOTAP induced migration of activated dendritic cells (DC) to the draining lymph node (DLN) and efficiently generated functional antigen-specific CD8+ T lymphocyte infiltration and apoptosis at tumor sites; the effect did not change by adding CpG to the same formulation [106].