Thereby the endogenous role of HDL as a nanocarrier for cholesterol was explored in synthetic HDL that carried cholesteryl-CpG, neo-antigens, and tumor Ag peptides (neo-antigens identified via tumor DNA sequencing) to produce homogeneous, stable, and ultrasmall nanodisks in less than two hours at room temperature; nanodisks promoted co-delivery of Ag/CpG to draining lymph nodes; prolonged Ag presentation on antigen-presenting cells (APCs); elicited striking levels of broad-spectrum antitumor T-cell responses; and significantly inhibited tumor growth, also eradicating established tumors [102]. Here, RENBP is linked to neoplasm.