When comparing survival in mice with Trp53-/- tumours, it was shown that there was no significant difference in survival of mice with Trp53-/-;Brca1-/- tumours (46 days), but Trp53-/-;Nf1-/- and Trp53-/-;Pten-/- tumours displayed significantly shorter survival (Table 2). This evidence concerns the gene BRCA1 and neoplasm.