PGP and cancer: This effect prompted us to test mWNVs-DOX in a model of drug resistance controlled by P-gp (an ATP-dependent transporter reported to confer resistance to a variety of drugs such as vinblastine, paclitaxel and DOX, [27] and being expressed in several types of cancer [28]), as per each internalisation event of an mWNV, a number of DOX molecules in the order of 105 are internalised, which can potentially overload P-gp and thus overcome resistance.