This study aimed to evaluate: (1) the effects of acute hyperglycemia on lung inflammation and edema in ALI, (2) the effects of acute hyperglycemia on the SGK1–NKCC1 pathways in ALI, and (3) the therapeutic effects of the NKCC1 inhibitor in lung injury with acute hyperglycemia. This evidence concerns the gene SGK1 and Hyperglycemia.