The patient studied here did not have a diagnosis of mastocytosis, however, they also had a total serum IgE concentration above the reference range (466 kU/L, reference range 0–81 kU/L) (Figure S3), and a history of allergic diseases including asthma, which can be exacerbated by certain foods, and contact dermatitis. This evidence concerns the gene IGHE and allergic disease.