CXCL8 and neoplasm: Contrastingly, basophils may exert pro-tumor activities, through release of pro-angiogenic and lymphangiogenic mediators, such as VEGF-A and VEGF-B, CXCL8, angiopoietin-1, hepatocyte growth factor, and tryptase [92,96,97], and may suppress anti-tumoral immune responses, such as through T-reg interactions [98,99].