Despite there being no prognostic value of tryptase concentration alone, either in the circulation or tumor (Figure S6), improved patient prognosis was maintained when the gene signature for activated basophils in ovarian tumors included tryptase (CD123, CCR3, FcεRI, CD63, CD203c and tryptase gene expression) (Figure 7B; PFS: HR = 0.72, p = 0.0055; median survival: T3 = 20 months (n = 209), T1 = 15 months (n = 204); OS: HR = 0.74, p = 0.03; median survival T3 = 45.8 months (n = 223), T1 = 36.8 months (n = 216)). Here, CD63 is linked to neoplasm.