The patient’s basophils were not activated by the anti-EGFR mAb, cetuximab, which has been widely reported to trigger hypersensitivity reactions in a subset of cancer patients who have IgE antibodies against galactose-alpha-1,3-galactose (alpha-gal), that decorates cetuximab [7,44,45,46] (Figure 3C–E). Here, EGFR is linked to cancer.