This decrease of Ku70 signal at the 3’ pause region of the β-actin gene was also seen in LN229 or G55 human glioblastoma cells infected with a lentivirus expressing a XRN2 shRNA (LN229-shXRN2 or G55-shXRN2) as compared to LN229 and G55 cells expressing a luciferase shRNA (Figure S5). The gene discussed is ACTB; the disease is glioblastoma.