At least six target genes were revealed, including p27Kip1, tyrosine-protein kinase Kit (c-KIT), ETS proto-oncogene 1 (ETS-1), AP-1 transcription factor subunit (c-FOS), Activating enhancer binding Protein 2 α (AP2α) and Stearoyl-CoA Desaturase 5 (SCD5), all with direct or indirect tumor suppressor roles according to the central roles of miR-221 and -222 in melanoma proliferation and dissemination [156,157,158,159,160]. This evidence concerns the gene ETS1 and melanoma.