BRAF and melanoma: More recently, the antiproliferative and cytotoxic effects of 2ME2 were shown in melanoma cells with different genetic backgrounds, as well as in the counterparts resistant to either BRAFi (v-raf murine sarcoma viral oncogene homolog B1) or the BRAFi+MEKi (Mitogen-Activated Protein Kinase Kinase) combination [53].