When overexpressed, these miRNAs act as oncogenes and are strongly implicated in T cell leukemia development by targeting myosin regulatory light chain-interacting protein (Mylip), retinoblastoma-binding protein 1-like (Rbp1-like), and homeodomain-interacting protein kinase 3 (Hipk3) [176]. The gene discussed is HIPK3; the disease is T-cell leukemia.