Similar to ATLL cells, Tax immortalized cells accumulate H3 lysine 27 trimethylation (H3K27me3) marks, responsible for chromatin condensation and gene silencing and can indirectly suppress diverse target genes through modulation of host epigenetic machinery via interaction with enhancer of zeste homolog 2 (EZH2), the active core subunit of polycomb repressive complex 2 (PRC2) [68]. The gene discussed is EZH2; the disease is adult T-cell leukemia/lymphoma.