IFNG and neoplasm: In addition, stimulation by tumor cells led to substantial cytokine release by CIK cells, as shown in Figure 3C. The production of IFN-gamma could be further dramatically augmented after 24 h of MDA-MB-231/CIK coculture in the presence of 7C6 mAb as compared with isotype IgG1 (469.1 ± 16.6 pg/mL vs. 142.3 ± 33.8 pg/mL, respectively).