However, several molecules have been shown to be associated with the proteolytic shedding of MICA and MICB, leading to the immune escape in advanced cancers, such as disulfide isomerase (ERp5) and ADAM (a disintegrin and metal-loproteinase) proteins and MMPs (matrix metalloproteinases) [21,22,23,24]. The gene discussed is MICA; the disease is cancer.