Interestingly, miR-101-3p upregulation reduced protein expression of COX-2 and MMP-1 in MDA231Br (Figure 6B), which shows that restoring miR-101-3p in breast cancer cells reduces their transmigration through the brain endothelium by reducing COX-2/MMP1 expression. This evidence concerns the gene PTGS2 and breast carcinoma.