Conventionally, PD can arise from dominant mutations in α-synuclein (SNCA), leucine-rich repeat kinase 2 (LRRK2), and vacuolar protein sorting-associated protein 35 (VPS35) genes, as well as recessive mutations in parkin (PARK2), phosphatase and tensin homolog-induced putative kinase 1 (PINK1), and DJ-1 (PARK7) genes [130,131]. Here, PRKN is linked to Parkinson disease.