PSEN2 and Alzheimer disease: Among them, circHOMER1 contains five predicted binding sites for miR-651, which is predicted to target PSEN1 and PSEN2 [91]; circCORO1C, which co-expressed with the APP and SCNA (an AD-related gene), contains two predicted binding sites for miR-105, an miRNA also shown to target APP and SNCA (α-synuclein).