The mammalian target of rapamycin (mTOR) kinase, one of the phosphatidylinositol kinase-related kinases, plays an essential role in PI3K/Akt pathway activation through assembling mTOR-complex 1 (mTORC1) and mTOR-complex 2 (mTORC2) in PCa [17–20]. This evidence concerns the gene AKT1 and posterior cortical atrophy.