The application of New Generation Sequencing (NGS) technology and open access to major databases has resulted in identification of several potential prognostic and early diagnostic biomarkers in HCC, including Protocadherin 19 (PCDH19) gene hypermethylation [10], Glypican-3 or GPC3 [11] and Cytochrome P450 Family 3 Subfamily A Member 4 or CYP3A4 [12]. This evidence concerns the gene CYP3A4 and hepatocellular carcinoma.