In conclusion, our study used WGCNA and LASSO regression analyses to identify five mRNAsi-related genes, namely, ANGPT2, EMCN, GLDN, USHBP1 and ZNF532. We then constructed a survival model with these five genes and successfully verified their accuracy, sensitivity and specificity to predict the prognosis of HCC patients in TGCA, ICGC and GEO databases. Here, ANGPT2 is linked to hepatocellular carcinoma.