On the basis of marker expression patterns, particularly of keratin 7, this theory has been challenged by Herfs et al15 These authors identified a small population of keratin 7‐positive cuboidal cells in the vicinity of the SqCJ, which were speculated to be the progenitors of high‐grade squamous intraepithelial lesions (HSIL). This evidence concerns the gene KRT7 and squamous cell intraepithelial neoplasia.