HIF1A and malignant colon neoplasm: Additionally, RT-qPCR demonstrated that HIF-1α mRNA was markedly overexpressed in colon cancer tissues (n=50) (Figure 7C, P<0.05), and Pearson’s analysis indicated that there was negative correlation between miR-217 and HIF-1α mRNA expression levels (Figure 7D, P<0.05).