However, LRRK2 kinase inhibitors had a reduced effect on the LRRK2 pS335 levels when macrophages were infected with M. tuberculosis and no effect after infection with L. monocytogenes (Fig EV1G–I), indicating that Rab8A pT72 and LRRK2 pS935 phosphorylation are decoupled events in macrophages. This evidence concerns the gene LRRK2 and infection.