PPARA and schizophrenia: To address the above issues, we designed the present study to explore the PPAR–SCZ association at three different levels: polymorphism of PPAR encoding genes, their expression levels within particular brain regions, and expression levels in peripheral blood mononuclear cells (PBMCs) collected from treatment-naïve patients with early-onset schizophrenia, in a hope to uncover new insights regarding the roles of the PPAR group in the pathological development of SCZ.