TRPM7 and cancer: Apart from IL-4, TRPM7 also regulates other signals pertinent to inflammation, such as caspase-dependent cleavage and extracellular pH, but there are still no practical method to promote the proliferation of macrophages through regulating the function of TRPM7 [58].In previous studies, TRPM7 has also been proved to be able to affect the proliferation of cancer cells.