Overexpression of TRPM7 has been reported to increase H2O2-mediated injury, suggesting that TRPM7 is a potential target for neurodegenerative diseases [26].In addition, scarcity of Ca2+ and Mg2+is responsible for guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G). Here, TRPM7 is linked to amyotrophic lateral sclerosis.