Then, the expression of four adenosine receptors (ARs): ADORA1, ADORA2A, ADORA2B and ADORA3 in PC were analysed, and the results indicated that ADORA2A, ADORA2B and ADORA3 were significantly up‐regulated in PC tissues (Figure 6B‐D), which was reported to be associated with tumour immune escape.8, 30. The gene discussed is ADORA2A; the disease is pachyonychia congenita.