A network of CD73/NT5E and its functionally related genes is shown in Figure S3A. Functional enrichment analysis of 21 genes above was conducted via Metascape and the results showed that p38α/β downstream pathway, cellar metal ion homeostasis, pathways in cancer, epithelial cell proliferation, response to inorganic substance were significantly regulated (Figure S3B). The gene discussed is NT5E; the disease is cancer.