NF2 and neurofibromatosis type 1: Health-related quality of life (QoL) is a complex multidimensional construct that depends on biological and psychological variables, symptoms, functional status, general health perceptions, and the influences of personal (eg, individual preferences) and environmental factors (eg, social support), as well as nonmedical factors.3 The clinical manifestations of NF1 and NF2 have profound effects and limitations on daily life activities, social roles, and mental health.