KIF11 and malignant peripheral nerve sheath tumor: There is a partial functional redundancy between the 2 studied spindle proteins: KIF15 can replace all essential functions of KIF11 in the creation of the bipolar spindle17 and a KIF15-dependent resistance to KIF11 inhibition has already been described in vitro.33,34 In our study, either a partial or a total genetic suppression of KIF15 conferred the MPNST cell line S462 to increase its sensitivity to KIF11 inhibition, supporting a functional role for both KIF11 and KIF15 in the survival of MPNST cells.