NF1 and plexiform neurofibroma: An epigenome study of MPNST and neurofibromas found that the methylome was different between high- and low-grade MPNST, the latter being indistinguishable from atypical neurofibroma.71 High-grade MPNSTs fell into two epigenomic subgroups regardless of neurofibromin status, correlating with presence of H3K27me3.