Overall, SCNAs do not appear to differentiate sporadic versus NF1-associated MPNST, whereas some studies found minor differences between the two types (e.g. gain of 4q more common in sporadic than NF1 MPNST).18,19 Nearly all aCGH studies reported substantially more SCNA gains than losses in MPNSTs, suggestive of greater oncogene influence in MPNST. Here, NF1 is linked to malignant peripheral nerve sheath tumor.