FBLN2 and sarcoma: In a genome-wide DNA methylation study of 10 MPNSTs and other sarcomas in 2013, although seven tumors failed to cluster among themselves (unsupervised analysis) or with other sarcomas based on overall methylation profile, the authors were able to identify a characteristic set of 38 methylated cytosines for MPNSTs with further analysis.65 The three most significant cytosines were in the FBLN2, MICALL2, and EFCAB1 genes respectively, and overall the study found hyper-methylation at the subgroup-specific cytosines.