TP53 and neoplasm: Molecular studies have reported TP53 tumor suppressor abnormalities (SNVs or SCNAs) in 40–75% of MPNSTs, with biallelic losses rare.27 Strong p53 immunostaining of tumor sections has been correlated with TP53 SNVs and poor survival.28,29MMP13 (11q22) was of interest as a possible marker of early transformation because of increased protein expression30; this is consistent with increased copy number in some aCGH studies,31,32 but is inconsistent with observation of genetic loss in Yang and Du,19 highlighting the heterogeneity within these tumors.