In mice, conditional ablation of Nf1 and Cdkn2a in Schwann cell lineage results in tumors that phenocopy human ANNUBP and frequently progress to MPNST.77 Another genomic study found that most ANFs have normal diploid genomes, low-somatic mutation load, and frequent NF1 inactivation and SCNAs in CDKN2A/B and SMARCA2. 8 Importantly, no mutations, SCNAs or changes in expression were detected in SUZ12, EED, or other PRC2 genes, in contrast with that published in most MPNSTs. Here, EED is linked to malignant peripheral nerve sheath tumor.