The review noted that cytogenetic abnormalities from over 100 MPNSTs were heterogeneous structurally and numerically, including ploidy (from hypodiploidy to near-tetraploidy), and with different clonal elements.15 There were no abnormalities specific to, or highly consistent within MPNST, although those derived from people with NF1 were more likely to show copy-number variants for chromosome 17 (including the NF1 gene locus) or have copy-neutral losses through isodisomy. This evidence concerns the gene NF1 and malignant peripheral nerve sheath tumor.