TP53 and malignant peripheral nerve sheath tumor: In both mouse and human MPNST, mutations or copy number alterations in genes such as TP53, CDKN2A, EGFR, and SUZ12 have all been reported as secondary cooperating mutations facilitating malignant progression.11–15 In this regard, alterations in TP53, EGFR, and SUZ12 are common in MPNST.