TP53 and cancer: A TP53 mutation is a genetic event that occurs in all types of cancer, and it is thought to be inactivated in the early stage of tumorigenesis.22 Furthermore, due to its function in centrosome duplication and in cell-cycle arrest, p53 has a role in genome stability.23,24 The high rate of TP53 alteration in gcGBM suggests that this gene has a main role in these tumors and that it could represent one of the earliest events in the gliomagenesis of gcGBMs.