FOXM1 is a downstream component of the Wnt signaling and is critical for β-catenin transcriptional function in tumor cells.15,16 Merlin destabilizes FOXM1 protein, which plays critical roles in aggressive meningiomas.32 We thus hypothesized that the Merlin/FOXM1/Wnt signaling axis may play an important role in NF2-associated meningiomas. The gene discussed is NF2; the disease is meningioma.