Over the past decades, our knowledge of meningioma genetics has expended exponentially; 4,5 however, the improvement of effective drug treatment has lagged behind.21–24NF2-mutant meningiomas often cause severe neurologic morbidity and mortality without clearly effective medical treatments.33,34 The tumor suppressor NF2 gene encodes for Merlin protein.12 In this study, we first screened Merlin expression in a large cohort through immunohistochemical staining. The gene discussed is NF2; the disease is meningioma.