Finally, interfering FOXM1 in CH157-MN cells resulted in decreased sensitivity to ICG-001 treatment (Fig. 5E), suggesting that ICG-001-mediated growth inhibition of Merlin-negative meningioma cells occurs, at least in part, by attenuating the FOXM1-mediated Wnt/β-catenin signaling. This evidence concerns the gene NF2 and meningioma.