IL6 and glioblastoma: In addition, DMF may also prevent lymphangiogenesis by suppressing endothelial cell growth and preventing capillary formation.6 Preclinical studies have identified that the expression of the proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha is decreased after activated microglial cells are exposed to DMF.7 IL-6 has been implicated in GBM cell invasion and angiogenesis.