EGFR and non-small cell lung carcinoma: EGFR-mt NSCLC (hazard ratio [HR] 0.62; confidence interval [CI] 0.39–0.98; P = .041), single BM (HR 0.61; CI 0.43–0.87; P = .0057), and local therapy (HR 0.60; CI 0.65–1.67; P = .0002) were associated with significantly longer survival after developing BMs, whereas poor performance status (HR 2.02; CI 1.22–3.21; P = .008) was significantly associated with poorer prognosis both in univariate and multivariate analyses (Table 2).