EGFR and cancer: Within the same glioblastoma, different cancer cell populations have been described with distinct genetic alterations including amplification of platelet-derived growth factor receptor alpha (PDGFRA) in combination with either epidermal growth factor receptor (EGFR) or MET (hepatocyte growth factor receptor) amplification.11,12 Furthermore, multiple studies have shown that intratumoral genetic heterogeneity is frequently occurring in glioblastoma, where different cancer cell subpopulations may communicate and depend on each other, like in a social network.13,14