Cell movement along white matter tracts, guided by axonal guidance proteins, is a well-known route of glioma cell invasion.45 This finding also validates our previous work using RNAseq and a smaller independent GB proteomics dataset n = 16, which found that PSMD3 was part of a network protein signature that predicted GB patient survival with more than 80% accuracy.46 In contrast, BAX, CASP1, GNB2L1, and VWA5A provided core p53 signaling enrichment in LTS. Here, PSMD3 is linked to central nervous system cancer.