• CD68 and Iba1 expression was found in 28/30 sporadic VS, 9/10 NF2-related schwannomas, and 4/4 Schwann cell tumors associated with schwannomatosis • M2-type macrophage marker MMR/CD206 was expressed in both sporadic and NF2-associated schwannomas. Here, AIF1 is linked to schwannomatosis.