TKT and central nervous system cancer: RRVs of non-primate origin have been reported to efficiently transduce glioma cells and thus refocused the translational attention of SGT involving γ-RVs.51 Since RRVs exhibit a non-lytic life cycle, the therapy is mostly dependent on the suicide gene activity which could be achieved by using CD or viral TK.45,51 While RRVs in general transduce only dividing cells, the high-transduction ability is conferred by the replicative nature of the vectors.