Thereby, similar results were obtained with significantly higher median ADC values for IDH-mutant astrocytomas with the presence of a T2/FLAIR-mismatch sign (median ADC of 1536 × 10–6 mm2/s [IQR, 1518–1572 × 10–6 mm2/s]) as compared to those without a T2/FLAIR-mismatch sign (median ADC of 1256 × 10–6 mm2/s [IQR, 1157–1376 × 10–6 mm2/s]) (P < .0001; Figure 4, bottom row). This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).