Differences in both ADC and rCBV values were found for IDH-mutant gliomas with the presence of a T2/FLAIR-mismatch sign as compared to IDH-mutant gliomas without the presence of a T2/FLAIR-mismatch sign (P < .0001 and P = .0123, respectively) (Figure 4, top row). The gene discussed is IDH1; the disease is central nervous system cancer.