TYRO3 and cancer: Noteworthy, AXL belongs to the TAM family of receptors (Tyro3-AXL-Mer),29 is involved in epithelial-to-mesenchymal transition (EMT) in cancer,30 and is described as a regulator of cell migration/invasion, especially in GBM.31,32 Protein analysis showed that AXL levels were significantly downregulated by rh-sLRIG1 addition in U87-derived cells, independent of their EGFR status (Figure 2D), and also upon sLRIG1 expression (Figure 2E).