In the clinical study on newly diagnosed GBM that is active at our institution, vaccinations with DCs loaded with whole tumor lysate were combined with TMZ chemotherapy administered as an adjuvant treatment in the context of the Stupp regimen.10 We obtained encouraging results in a fraction of these patients (45%), associated with a rise of active NK cells in peripheral blood; however, the contribution of CD8+ T cells to antitumor activity and the memory status generation was negligible. The gene discussed is CD8A; the disease is glioblastoma.