PRL and hyperprolactinemia: Exclusion criteria were case reports or studies of less than 5 cases, and studies assessing prolactin changes in psychotic patients for whom the main reason for the therapeutic strategy was not hyperprolactinaemia (e.g., switching in treatment-resistant patients).Although the systematic review included clinical trials and observational studies, only randomized clinical trials (RCTs) were considered for conducting a meta-analysis.