Because ACE2 is also highly expressed in the heart, COVID-19 induced cardiac injury might potentially be mediated by ACE2, although whether SARS-CoV-2 binding alters ACE2 expression or causes dysregulation of the renin-angiotensin-aldosterone system (RAAS) pathway remains unclear [6,7,32,33]. The gene discussed is ACE2; the disease is COVID-19.