This was measured by skin prick testing and serum allergen-specific IgE in a separate study of more than 50,000 10-11-year-old children in 30 centres from 22 countries (ISAAC Phase Two).3, 4, 5,27 Although (as expected) symptoms of rhinoconjunctivitis, asthma and eczema were more common among children with positive skin prick tests, these associations were substantially weaker in less affluent settings. The gene discussed is IGHE; the disease is Eczematoid dermatitis.