In contrast, deletion of Sirt6 had significant negative effects on CD-exerted protection in podocytes, as evidenced by the ACR, glomerulosclerosis, foot processes fusion and apoptosis rates of podocytes in Sirt6flox/flox/Nphs2-Cre+ mice treated with CD, which remained high (Figure 5D-5F and Figure S4B), in contrast, the above indicators in the other three treatment groups were essentially normal (Figure 5D-5F). The gene discussed is SIRT6; the disease is glomerulosclerosis.