ACE2 and severe acute respiratory syndrome: scRNA-seq data analyses recently revealed that ACE2 is highly expressed in organs at risk for injury in the context of COVID-19 and SARS, including lung, heart, esophagus, kidney, bladder, ileum, oral mucosa, and specific cell types (e.g., type II alveolar cells (AT2) in lung, myocardial cells, proximal tubule cells of the kidney, ileum and esophagus epithelial cells, and bladder urothelial cells) 42, 71.