For instance, we noted significant downregulation of major vault protein (MVP) in FUS-exposed GEVs (p<0.0001); MVP is thought to be a miRNA-binding protein with a role in sorting miRNA to exosomes, is overexpressed in multidrug-resistant cancer cells 27,28 and has also been demonstrated to support glioblastoma (GBM) survival and migration 29. The gene discussed is MVP; the disease is glioblastoma.