FGFR3 and microcephaly: We found that XAV939 treatment also partially rescue the domed-shaped skulls and microcephaly of fgfr3 mutants, we speculated that this is via improving the chondrogenic phenotype such as in jaw cartilage and cranial base cartilage, which may lead to improvement of cranial skeletal asymmetry and abnormal mechanics in fgfr3 mutants.