The dwarfism phenotypes in ACH patients and mouse models, as well as the skeletal overgrowth with tall stature in CATSHL syndrome patients and Fgfr3 deficient mice strongly demonstrate that FGFR3 is a negative regulator of development of endochondral bone 4,8. Here, FGFR3 is linked to Camptodactyly - tall stature - scoliosis - hearing loss.