Our data suggest that the development of cartilage is conserved between zebrafish and mammals, and our fgfr3 deficient zebrafish model can be used to study the role of FGFR3 in chondrogenesis and screen therapeutic molecules for FGFR3 related genetic diseases including CATSHL and ACH by taking the advantages of zebrafish. The gene discussed is FGFR3; the disease is hereditary disease.