FGFR3 and microcephaly: We analyzed their effect at 30 dpf (SL 10.0 mm) and 40 dpf (SL 13.0 mm), and found that the abnormal drooping of hyoid arch in fgfr3 mutants was partially alleviated by XAV939 (Figure 9D and Figure S8A), the domed-shaped skulls and microcephaly also were partially alleviated (Figure 9D).