We found that the fgfr3 mutant zebrafish have severe craniofacial bone malformation, as evidenced by microcephaly with smaller cranial skull bones and delayed closure of cranial sutures, drooped hyoid arch and midface hypoplasia, which to some extent resembles the clinical manifestations of CATSHL syndrome patients 3. The gene discussed is FGFR3; the disease is Camptodactyly - tall stature - scoliosis - hearing loss.