In this context, it has also been shown that the peroxisome proliferator activated receptor-γ (PPARγ), which is a prototypical ligand-activated nuclear receptor play an important role in coordination of lipid, glucose, and energy metabolism and agonists of this receptor have been found to be effective in the reduction of inflammation and memory impairment associated with AD (7, 8). Here, PPARG is linked to Alzheimer disease.