CD8A and neoplasm: The observation that PD-1 expression is increased in CD8+ T-cells at tumour regrowth following 3 × 5 Gy RT suggests the presence of T-cell exhaustion in TRAMP-C1, and the reduced CD8+ T-cell, helper T-cell, and DC gene expression on NanoString analysis in radio-recurrent compared with control untreated tumours suggests an immunosuppressed TIME at eventual tumour re-growth.