Whilst RT doses in the literature are higher than the 3 × 5 Gy used in our experiments, our observation of an increase in CD11b+F4/80+ expressing TAMs 7-days post-3 × 5 Gy is consistent with observations in TRAMP-C1.14 TAMs are myeloid cells present in many solid-organ tumours including PCa, and they demonstrate functional plasticity, differentiating into various phenotypes during inflammatory responses. Here, ITGAM is linked to posterior cortical atrophy.