Pre-clinical studies demonstrate that tumour cell MHC-I expression is a surrogate marker of immunogenicity, and correlates with increased cytotoxic T-cells in the TIME and increased response of tumour models to immunotherapy, with an inverse relation to tumour growth rate.47,48 We investigated baseline in vitro cell surface expression of MHC-I and PD-L1 in TRAMP-C1 and MyC-CaP cells, along with the response to γIFN, as a measure of de novo immunogenicity. The gene discussed is CD274; the disease is neoplasm.