Next, we determined that reconstitution of p190A expression is sufficient to activate the Hippo pathway and restore CIP in vitro, as well as repress tumorigenesis in athymic mice, thus providing conclusive evidence of a tumor suppressor function for ARHGAP35. It is established that YAP can functionally substitute for oncogenic RAS in cancer [56, 57]. The gene discussed is ARHGAP35; the disease is hereditary sensory and autonomic neuropathy.