Due to a higher incidence of COVID-19 in males, the direct role of TMPRSS2 gene in the infection, and the potential association between inflammation and prostate cancer, studies that critically address the impact of inflammatory cytokines TNF, IL-1β, IL-6, and IL-8 on prostate cancer can help us to better understand the impact of COVID19 on prostate cancer etiology and carcinogenesis. Here, TNF is linked to Familial prostate cancer.