For example, PIM2 could inhibit apoptosis of cancer cells through activating API-524, or through phosphorylating BAD on Serine 11225; PIM2 is required for cell growth and proliferation of multiple myeloma26,27; and PIM2 was found to be upregulated by the treatment of cisplatin and limited its efficacy in ovarian cancer cells28. This evidence concerns the gene BAD and ovarian cancer.