In addition, the fold changes in luciferase activity for the engineered cells over the non-tumor reactive TCR Control 1 cells ranged between ~12 and ~90.3-fold (Fig. 7b), comparable or higher to the previously identified TCR41 (Supplementary Fig. 7c) highlighting the potency of the TCRs from the expanded clones in the tumors from Aire−/− mice. Here, AIRE is linked to neoplasm.