It is possible that the autoimmunity observed in Aire−/− mice and humans with APECED results in higher levels of circulating chemokines such as Cxcl9 and Cxcl10 produced by macrophages or dendritic cells which when present in tumors leads to enhanced recruitment of T cells, supporting an intricate feedback loop between innate and adaptive immune cells in orchestrating an enhanced antitumor response in Aire−/− mice. This evidence concerns the gene AIRE and Autoimmunity.