Interestingly, chemokine profiling revealed higher levels of CXCL10 in the serum from Aire-/- mice (Supplementary Fig. 2d) in agreement with previous reports showing high levels of CXCL10 in APS-1 patients27, suggesting a potential mechanisms for the enhanced antitumor response. This evidence concerns the gene CXCL10 and autoimmune polyendocrine syndrome type 1.