Cytokines secreted by tumors, such as Interleukin-1 (IL-1), IL-6, tumor necrosis factor-α (TNF-α), G-CSF and granulocyte-macrophage colony stimulating factor (GM-CSF) contribute to leukocytosis and neutrophilia23,24.These cytokines are closely related to inflammation and are now considered to be the key ingredients to tumor development25. This evidence concerns the gene TNF and neoplasm.